Thank you , with so many charities popping up , since COVID , looking for diagnosis , rather than cures , whether the whole system needs to be re-educated and restructured ?
One thing I'd like to mention about Keto diets being used to starve cancer cells, due to the Warburg effect is that high fat diets may help but shouldn't be continued too long. The problem is that prolonged keto can alter the gut microbiome and damage the intestinal lining. This was recently outlined in a Mercola article summary:
"Chronic high-fat diets raise stress hormones, overload serotonin in your gut, and weaken your intestinal barrier, creating a cycle of inflammation that spreads throughout your body
Excess dietary fat disrupts gut-brain communication, leaving your digestive system inflamed while key brain regions involved in mood, memory, and appetite are deprived of proper chemical signaling
High-fat eating patterns alter gut bacteria in ways that increase harmful microbes, reduce immune regulation, and allow bacterial toxins to enter your bloodstream and fuel systemic inflammation
Elevated cortisol from high-fat diets locks your body into a prolonged stress response, worsening fatigue, metabolic dysfunction, digestive instability, and poor stress tolerance
Restoring balance requires addressing root causes by moderating fat intake, eliminating vegetable oils, rebuilding carbohydrate-driven energy metabolism, and supporting gut repair and cellular energy"
Thanks Ionedery2! What are your thoughts for people targetting low serum glucose levels, with low glucose to ketone ratios? It takes months to have the desired cancer suppresive effects. How long do you think this diet is well toerated without having the negative effects you describe? Are there remedial actions that can be taken in the meantime, for instance pro-healthy gut biome actions that can be taken while they are achieveing the low glucose to ketone ratios?
I think maybe a keto diet could jumpstart a metabolic reset for some people. I've tried it myself for at least 2 months without any problems but there was no need to continue in my case as I'm not overweight and don't have cancer. I thought it was healthy and was going to continue indefinitely until I read a few articles like the Mercola one.
I think reducing glucose is important though so learning the glycemic index of the foods you eat could help for starters. Complex carbs could be chosen to slow the absorption of glucose if tolerated. Adding sufficient protein with meals can also slow glucose absorption in the gut. Another strategy is targeted fitness and strength training which would improve glucose uptake in the muscles and reduce insulin resistance +lower blood sugar. There are also targeted supplements like berberine and gut microbes like Akkermansia. The right kind of fat is important too, stable ones like butter and coconut oil instead of industrial seed oils will save the mitochondria from further harm. Mercola thinks 30% fat or less is a good dietary rule.
I’d be a bit cautious about taking Joseph Mercola at face value here. Some of these claims (like chronically elevated cortisol, “serotonin overload,” or gut barrier damage) aren’t really well established in human research and feel like a stretch from limited or animal data.
It also really depends on what kind of keto we’re talking about. A whole-food approach (grass-fed/finished animal protein, dairy, vegetables, berries, fermented foods) is very different from a high-fat, low-fiber, processed version. Historically, humans likely ate more animal-based diets with seasonal or gathered plant intake, not the constant, high volume of vegetables or processed “keto” foods we see now. A lot of the negative gut findings tend to come from the more modern, processed version.
While most serotonin is made in the gut the idea that high-fat diets “overload” it and disrupt brain signaling isn’t clearly supported.
There’s also some interesting work from Georgia Ede looking at keto and even carnivore approaches for mental health. There's evidence to suggest that returning to ancestral ways of eating positively impacts both the body and brain. And researchers like Benjamin Bikman have shown that insulin resistance and how the body handles carbs vs. fat, is a big part of the picture, which again makes it more nuanced than just blaming fat intake alone.
Thanks Kendra for your comment. I agree that the fat vs. carb issue is more nuanced than I thought at first. I also am wary about Mercola articles or any articles that aren't based on solid scientific evidence.
There's still a lot to learn about insulin resistance and how to correct it or prevent it which could be relevant here. It seems to be at the core of a lot of metabolic problems but I don't know how effective conventional treatments are.
I'm curious and skeptical about these things and willing to change my mind when something doesn't add up. It sometimes seems like the more I learn about metabolism and intricate interconnected systems constantly adjusting and adapting, the more I'm astounded by the amazing resiliance and ability to heal that we have.
I agree that we definitely have the ability to heal ourselves and diet is just one of many tools. I just completed my certification as a nutritional therapy practitioner with a focus on nutrient dense food, sleep, digestion, blood sugar regulation and stress. Sleep is foundational for optimal health. I like the book Why We Sleep for a comprehensive overview and Sleep Smarter for practical strategies. Sleep also ties into our circadian rhythm and light exposure which ties into stress and blood sugar regulation. Huberman is a big fan of sunlight (red light) and he's had some interesting guests on his podcast (Peter Attia, Glen Jeffrey). Recently, he's been talking about LED light and the negative effects on blood sugar regulation. (I predict we're going to be moving back to incandescent bulbs - at least for some of our lighting). It's wild. I'm reading a book now called The Comfort Crisis. It explores how the more we move away from our natural environment - light, sound, nature, food, water (Pierre Kory's substack on structured water is interesting) - the more unhealthy and unhappy we are. Thanks for responding :)
Thanks Kendra and Ionedery! I am enjoying this enlightened exchange. I am reminded of a saying I often share with my medical students: "We are children playing with God's toys" This keeps us humble but constantly learning and reconsidering.
Lonedery2, thanks for sharing this info from Dr. Mercola! I’m very concerned about the extreme pendulum swing from low/no fat to low/no carbs. The truth is we need GOOD fats and GOOD carbs in our diets.
I’m a huge admirer of Dr. Paul Marik and have followed his papers in the journals for years, having been especially impressed with his work on vitamin C. With cancer sufferers, I’ve seen very favorable results with the techniques developed by Dr. Eli Jones, an American Eclectic physician of late 1800s and early 1900s. This amazing healer had decades of formal education from various schools and practiced for forty years. He is considered one of the greatest oncologists of all time, credited with an 80% cure rate--something no oncologist of today could even hope to boast. Towards the end of his career, he wrote the remarkable book entitled Cancer: Its Causes, Symptoms, and Treatment, which has been reprinted and is still available today. As for diet, it is absolutely crucial—not only what we should consume but also what we should not consume. In this regard, there is one commonly consumed beverage that has been powerfully linked with several types of cancer and, unfortunately, that is coffee, one of the world’s most popular drinks. However, this information has largely been unavailable to the public… until now: See my Substack on this here: https://matthewalfs.substack.com/p/the-dark-side-of-coffee
Matthew: The pros and cons of coffee seems to be a moving target; with strong sound advocates for and against coffee.
Here is a fine demonstration of the complexity, and often contradictory findings in science. This 2016 large meta-analysis of 105 prospective studies found coffee intake linked to reduced risk of oral, pharyngeal, liver, colon, prostate, endometrial cancer, and melanoma. https://www.nature.com/articles/srep33711
PLEASE WATCH THIS VERY INTERESTING VIDEO ABOUT TERRAIN FACTS... NOT THEORY. LIKE THE BROTHER, JOSHUA & ADAM BIGELSEN SAYS. WHEN YOU UNDERSTAND NATURE, YOU UNDERSTAND HOW THE BODY WORKS.
I am pretty sure that you will be impress by their work and all that they do and... their personality. Great men. I'm sure you'll get along pretty good, for me knowing about the 3 of you's personality. I can feel it! :)
Thanks for the like, Dr. Trozzi! An interesting addendum on Dr. Jones: he would inject anal and vaginal cancers with thuja (Thuja occidentalis) tincture, 10-20 drops, every other day, and it would cause the tumor to slough off. He would then combine the tincture with glycerine, half-and-half, and paint it on three times a day, and would give the tincture orally as well (pages 166 and 207 of his book) and the patients would eventually become cancer-free. As we now know, many vaginal and anal cancers are HPV-caused; yet, Jones knew nothing about that. However, thuja has long been the standard treatment in natural medicine for warts (including in Jones’ day), another HPV-caused affliction, and studies have shown efficacy against papillomaviruses (Beuscher, N. and L. Kopanski. 1986. “Purification and Biological Characterization of Antiviral Substances from Thuja occidentalis,” Planta Med 52:555-56). European research has also demonstrated that thuja stimulates T cells and the production of interleukin 2 (IL-2), endogenous cancer fighters. (Gohla, S. H. et al. 1988. “Mitogenic Activity of High-molecular Polysaccharide Fractions Isolated from the Cupressaceae Thuja occidentale L. I. Macrophage-dependent Induction of CD-4-positive T-helper (Th+) Lymphocytes,” Leukemia 2:528-33.) Imagine if today’s oncologists studied Jones’ work and applied his techniques: the life of actress Farrah Fawcett, who had anal cancer--and so many others--might have been saved!
Thank you , with so many charities popping up , since COVID , looking for diagnosis , rather than cures , whether the whole system needs to be re-educated and restructured ?
I thank God for doctors like Paul Marik who think outside the box!
And you too, Dr. Trozzi!!! ❤️
One thing I'd like to mention about Keto diets being used to starve cancer cells, due to the Warburg effect is that high fat diets may help but shouldn't be continued too long. The problem is that prolonged keto can alter the gut microbiome and damage the intestinal lining. This was recently outlined in a Mercola article summary:
"Chronic high-fat diets raise stress hormones, overload serotonin in your gut, and weaken your intestinal barrier, creating a cycle of inflammation that spreads throughout your body
Excess dietary fat disrupts gut-brain communication, leaving your digestive system inflamed while key brain regions involved in mood, memory, and appetite are deprived of proper chemical signaling
High-fat eating patterns alter gut bacteria in ways that increase harmful microbes, reduce immune regulation, and allow bacterial toxins to enter your bloodstream and fuel systemic inflammation
Elevated cortisol from high-fat diets locks your body into a prolonged stress response, worsening fatigue, metabolic dysfunction, digestive instability, and poor stress tolerance
Restoring balance requires addressing root causes by moderating fat intake, eliminating vegetable oils, rebuilding carbohydrate-driven energy metabolism, and supporting gut repair and cellular energy"
Thanks Ionedery2! What are your thoughts for people targetting low serum glucose levels, with low glucose to ketone ratios? It takes months to have the desired cancer suppresive effects. How long do you think this diet is well toerated without having the negative effects you describe? Are there remedial actions that can be taken in the meantime, for instance pro-healthy gut biome actions that can be taken while they are achieveing the low glucose to ketone ratios?
I think maybe a keto diet could jumpstart a metabolic reset for some people. I've tried it myself for at least 2 months without any problems but there was no need to continue in my case as I'm not overweight and don't have cancer. I thought it was healthy and was going to continue indefinitely until I read a few articles like the Mercola one.
I think reducing glucose is important though so learning the glycemic index of the foods you eat could help for starters. Complex carbs could be chosen to slow the absorption of glucose if tolerated. Adding sufficient protein with meals can also slow glucose absorption in the gut. Another strategy is targeted fitness and strength training which would improve glucose uptake in the muscles and reduce insulin resistance +lower blood sugar. There are also targeted supplements like berberine and gut microbes like Akkermansia. The right kind of fat is important too, stable ones like butter and coconut oil instead of industrial seed oils will save the mitochondria from further harm. Mercola thinks 30% fat or less is a good dietary rule.
I’d be a bit cautious about taking Joseph Mercola at face value here. Some of these claims (like chronically elevated cortisol, “serotonin overload,” or gut barrier damage) aren’t really well established in human research and feel like a stretch from limited or animal data.
It also really depends on what kind of keto we’re talking about. A whole-food approach (grass-fed/finished animal protein, dairy, vegetables, berries, fermented foods) is very different from a high-fat, low-fiber, processed version. Historically, humans likely ate more animal-based diets with seasonal or gathered plant intake, not the constant, high volume of vegetables or processed “keto” foods we see now. A lot of the negative gut findings tend to come from the more modern, processed version.
While most serotonin is made in the gut the idea that high-fat diets “overload” it and disrupt brain signaling isn’t clearly supported.
There’s also some interesting work from Georgia Ede looking at keto and even carnivore approaches for mental health. There's evidence to suggest that returning to ancestral ways of eating positively impacts both the body and brain. And researchers like Benjamin Bikman have shown that insulin resistance and how the body handles carbs vs. fat, is a big part of the picture, which again makes it more nuanced than just blaming fat intake alone.
Thanks Kendra for your comment. I agree that the fat vs. carb issue is more nuanced than I thought at first. I also am wary about Mercola articles or any articles that aren't based on solid scientific evidence.
There's still a lot to learn about insulin resistance and how to correct it or prevent it which could be relevant here. It seems to be at the core of a lot of metabolic problems but I don't know how effective conventional treatments are.
I'm curious and skeptical about these things and willing to change my mind when something doesn't add up. It sometimes seems like the more I learn about metabolism and intricate interconnected systems constantly adjusting and adapting, the more I'm astounded by the amazing resiliance and ability to heal that we have.
I agree that we definitely have the ability to heal ourselves and diet is just one of many tools. I just completed my certification as a nutritional therapy practitioner with a focus on nutrient dense food, sleep, digestion, blood sugar regulation and stress. Sleep is foundational for optimal health. I like the book Why We Sleep for a comprehensive overview and Sleep Smarter for practical strategies. Sleep also ties into our circadian rhythm and light exposure which ties into stress and blood sugar regulation. Huberman is a big fan of sunlight (red light) and he's had some interesting guests on his podcast (Peter Attia, Glen Jeffrey). Recently, he's been talking about LED light and the negative effects on blood sugar regulation. (I predict we're going to be moving back to incandescent bulbs - at least for some of our lighting). It's wild. I'm reading a book now called The Comfort Crisis. It explores how the more we move away from our natural environment - light, sound, nature, food, water (Pierre Kory's substack on structured water is interesting) - the more unhealthy and unhappy we are. Thanks for responding :)
Thanks Kendra and Ionedery! I am enjoying this enlightened exchange. I am reminded of a saying I often share with my medical students: "We are children playing with God's toys" This keeps us humble but constantly learning and reconsidering.
Lonedery2, thanks for sharing this info from Dr. Mercola! I’m very concerned about the extreme pendulum swing from low/no fat to low/no carbs. The truth is we need GOOD fats and GOOD carbs in our diets.
I’m a huge admirer of Dr. Paul Marik and have followed his papers in the journals for years, having been especially impressed with his work on vitamin C. With cancer sufferers, I’ve seen very favorable results with the techniques developed by Dr. Eli Jones, an American Eclectic physician of late 1800s and early 1900s. This amazing healer had decades of formal education from various schools and practiced for forty years. He is considered one of the greatest oncologists of all time, credited with an 80% cure rate--something no oncologist of today could even hope to boast. Towards the end of his career, he wrote the remarkable book entitled Cancer: Its Causes, Symptoms, and Treatment, which has been reprinted and is still available today. As for diet, it is absolutely crucial—not only what we should consume but also what we should not consume. In this regard, there is one commonly consumed beverage that has been powerfully linked with several types of cancer and, unfortunately, that is coffee, one of the world’s most popular drinks. However, this information has largely been unavailable to the public… until now: See my Substack on this here: https://matthewalfs.substack.com/p/the-dark-side-of-coffee
Thanks Matthew.
Friends, here is a link for free access to that book that Matthew reccomended by Dr Jones: https://archive.org/details/canceritscauses00jonegoog/page/10/mode/2up
Matthew: The pros and cons of coffee seems to be a moving target; with strong sound advocates for and against coffee.
Here is a fine demonstration of the complexity, and often contradictory findings in science. This 2016 large meta-analysis of 105 prospective studies found coffee intake linked to reduced risk of oral, pharyngeal, liver, colon, prostate, endometrial cancer, and melanoma. https://www.nature.com/articles/srep33711
PLEASE WATCH THIS VERY INTERESTING VIDEO ABOUT TERRAIN FACTS... NOT THEORY. LIKE THE BROTHER, JOSHUA & ADAM BIGELSEN SAYS. WHEN YOU UNDERSTAND NATURE, YOU UNDERSTAND HOW THE BODY WORKS.
https://www.universityofterrain.com/Hidden_Side_of_Healthcare_FREE_Training?cid=85b947b4-660c-4c4b-9ff5-3e20afb0b960
Thanks Christiane!
I am pretty sure that you will be impress by their work and all that they do and... their personality. Great men. I'm sure you'll get along pretty good, for me knowing about the 3 of you's personality. I can feel it! :)
Thanks for the like, Dr. Trozzi! An interesting addendum on Dr. Jones: he would inject anal and vaginal cancers with thuja (Thuja occidentalis) tincture, 10-20 drops, every other day, and it would cause the tumor to slough off. He would then combine the tincture with glycerine, half-and-half, and paint it on three times a day, and would give the tincture orally as well (pages 166 and 207 of his book) and the patients would eventually become cancer-free. As we now know, many vaginal and anal cancers are HPV-caused; yet, Jones knew nothing about that. However, thuja has long been the standard treatment in natural medicine for warts (including in Jones’ day), another HPV-caused affliction, and studies have shown efficacy against papillomaviruses (Beuscher, N. and L. Kopanski. 1986. “Purification and Biological Characterization of Antiviral Substances from Thuja occidentalis,” Planta Med 52:555-56). European research has also demonstrated that thuja stimulates T cells and the production of interleukin 2 (IL-2), endogenous cancer fighters. (Gohla, S. H. et al. 1988. “Mitogenic Activity of High-molecular Polysaccharide Fractions Isolated from the Cupressaceae Thuja occidentale L. I. Macrophage-dependent Induction of CD-4-positive T-helper (Th+) Lymphocytes,” Leukemia 2:528-33.) Imagine if today’s oncologists studied Jones’ work and applied his techniques: the life of actress Farrah Fawcett, who had anal cancer--and so many others--might have been saved!